DCE and DW-MRI monitoring of vascular disruption following VEGF-Trap treatment of a rat glioma model
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چکیده
منابع مشابه
DCE and DW-MRI monitoring of vascular disruption following VEGF-Trap treatment of a rat glioma model.
Vascular-targeted therapies have shown promise as adjuvant cancer treatment. As these agents undergo clinical evaluation, sensitive imaging biomarkers are needed to assess drug target interaction and treatment response. In this study, dynamic contrast enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DW-MRI) were evaluated for detecting response of intracerebral 9 L gliosarcomas to the antivas...
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Introduction Dynamic contrast enhanced MRI (DCE-MRI) is used to characterize perfusion and extracellular volume in tumors through the tracer kinetic modeling of MRI contrast agents (typically Gd-DTPA). However, the parametric estimates resultant of DCE-MRI may be influenced by several confounding factors, including inter-compartmental water exchange [1]. In contrast to MRI contrast agents, radi...
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آب حاصل از بارش منبع تأمین نیازهای بی شمار جانداران به ویژه انسان است و هرگونه کاهش در کم و کیف آن مستقیماً حیات موجودات زنده را تحت تأثیر منفی قرار می دهد. نوسان سال به سال بارش از ویژگی های اساسی و بسیار مهم بارش های سالانه ایران محسوب می شود که آثار زیان بار آن در تمام عرصه های اقتصادی، اجتماعی و حتی سیاسی- امنیتی به نحوی منعکس می شود. چون میزان آب ناشی از بارش یکی از مولفه های اصلی برنامه ...
15 صفحه اولDifferential effects of VEGF-trap on benign and malignant human melanoma xenografts evaluated by DCE MRI
Introduction K, the first order rate constant, that describes the transfer of contrast agent molecules from the vasculature to the interstitium, is a non-invasive indicator of changes in perfusion and/or permeability of tumor capillaries induced by antiangiogenic drugs. Based on our previous development of a DCE MRI protocol which permits simultaneous measurement in mice the arterial input func...
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ژورنال
عنوان ژورنال: NMR in Biomedicine
سال: 2011
ISSN: 0952-3480
DOI: 10.1002/nbm.1814